S12-01 MicroRNAs and morphogens
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منابع مشابه
S12-01 MicroRNAs and morphogens
Drosophila tracheal terminal branches are plastic and have the capacity to sprout-out projections towards oxygen-starved areas, in a process analogous to mammalian angiogenesis. It was previously shown that this sprouting response involves the upregulation of the FGF homolog Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells, thereby attracting the outgrowth of...
متن کاملMorphogens
Hands have five fingers, with each finger different and arranged in a particular order. Obvious perhaps, but the way that this arrangement is achieved during development has intrigued developmental biologists for decades. How do the cells of the hand know whether to form a thumb, index or little finger? More generally, how do cells know where they are within a tissue so that they form the appro...
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Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postul...
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revealed a marked reduction in radial thickness starting at E13.5, and defective postnatal cortical layering. Whereas the former was due to neuronal apoptosis starting at E12.5, which was the earliest detectable phenotype, the latter reflected dramatic impairment of neuronal differentiation. Remarkably, the primary target cells of Dicer ablation, the neuroepithelial cells, and the neurogenic pr...
متن کاملMorphogens, their identification and regulation.
During the course of development, cells of many tissues differentiate according to the positional information that is set by the concentration gradients of morphogens. Morphogens are signaling molecules that emanate from a restricted region of a tissue and spread away from their source to form a concentration gradient. As the fate of each cell in the field depends on the concentration of the mo...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.972